2024

Identification and characterization of the Bacillus subtilis spore germination protein GerY
(Journal of Bacteriology) Rudner Lab

DMS-MapSeq Analysis of Antisense Oligonucleotide Binding to lncRNA PANDA 
(Current Protocols) Rouskin Lab

Animal and bacterial viruses share conserved mechanisms of immune evasion
(Cell) Kranzusch Lab

Adipose tissue–gut microbiome crosstalk in inflammation and thermogenesis
(Trends in Endocrinology & Metabolism) Kostic Lab

Dissecting host–microbe interactions with modern functional genomics
(Current Opinion in Microbiology) Jost Lab

Viral RNA Interactome: The Ultimate Researcher’s Guide to RNA–Protein Interactions
(Viruses) Rouskin Lab

A prophage competition element protects Salmonella from lysis
(Cell Host & Microbe) Helaine Lab

Untangling the pseudoknots of SARS-CoV-2: Insights into structural heterogeneity and plasticity
(Current Opinion in Structural Biology) Rouskin Lab

Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
(Cell) Abraham Lab

Co-ordinated assembly of the multilayered cell envelope of Gram-negative bacteria
(Curr Opin Microbiol) Bernhardt Lab 

A coordinated attack by a bacterial secretion system and a small molecule drives prey specificity
(Communications Biology) Mekalanos Lab 

Differential Drug Susceptibility across Trichomonasvirus Species Allows for Generation of Varied Isogenic Clones of Trichomonas vaginalis
(Pathogens) Nibert Lab 

Structure and assembly of a bacterial gasdermin pore
(Nature) Kranzusch Lab

Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder
(PNAS) Helaine Lab

Structural basis for VLDLR recognition by eastern equine encephalitis virus
(Nature Comm) Abraham Lab

Dissecting OGT's TPR domain to identify determinants of cellular function
(PNAS) Walker Lab

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall
(Nat Microbiol) Bernhardt Lab

Shifts in receptors during submergence of an encephalitic arbovirus
(Nature) Abraham Lab

Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis
(PLoS Biol) Rudner Lab

FacZ is a GpsB-interacting protein that prevents aberrant division-site placement in Staphylococcus aureus 
(Nat Microbiol) Bernhardt and Rudner Labs

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection 
(PLoS Pathog) Helaine Lab

Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections 
(mBio) Gehrke Lab

Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators 
(mBio) Knipe Lab

Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells 
(Journal of Virology) Sodroski Lab

Tracing the evolutionary origins of antiviral immunity 
(PLOS Biology) Kranzusch Lab

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa 
(Nature Microbiology) Bernhardt Lab

Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics 
(PNAS) Hochschild Lab

Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation 
(ACS infect Dis) Schmidt Lab

SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination 
(Genes Dev.) Rudner Lab

Structural basis of Gabija anti-phage defence and viral immune evasion 
(Nature) Kranzusch Lab

2023

Decline in nitrosative stress drives antibiotic persister regrowth during infection
(Cell Host Microbe) Helaine Lab

Nuclear interferon-stimulated gene product maintains heterochromatin on the herpes simplex viral genome to limit lytic infection 
(PNAS) Knipe Lab

V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
(Journal of Virology) Sodroski Lab

A role for the Gram-negative outer membrane in bacterial shape determination 
(PNAS) Bernhardt Lab

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis 
(PNAS) Rudner Lab

MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases 
(mBio) Bernhardt and Rudner Labs

How Dormant Bacteria Return to Life 
(HMS News&Research) Rudner Lab

The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes 
(PNAS) Rudner Lab

Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus 
(Antimicrobial Agents and Chemotherapy) Walker Lab

Bacterial spore germination receptors are nutrient-gated ion channels 
(Science) Rudner Lab

RNA levers and switches controlling viral gene expression 
(Trends in Biochemical Sciences) Rouskin Lab

Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles 
(Journal of Virology) Sodroski Lab

A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW 
(Angewandte Chemie) Walker Lab

Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems 
(mSystems) Kostic Lab

IFNγ is a central node of cancer immune equilibrium 
(Cell Reports) Knipe and Dougan Labs

Silvi Rouskin talks about understanding and using RNA to treat human disease 
(Science Matters) Rouskin Lab

Key Molecules for Bacterial Growth, Infection Identified 
(HMS News & Research) Rudner Lab

Coordination of bacterial cell wall and outer membrane biosynthesis 
(Nature) Bernhardt and Walker Labs

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex 
(Cell) Kranzusch Lab

Invasion of the germinal centers 
(Cell) Schmidt Lab

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases 
(Science Immunology) Kranzusch Lab

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