2022
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors (eLife)
Jost Lab
Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness (NanoToday)
Gehrke Lab
Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design (Cell Reports Medicine)
Schmidt Lab
The emerging landscape of spatial profiling technologies (Nature Review Genetics)
Moffitt Lab
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells (Biochemistry)
Rouskin Lab
Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis (Microbiome)
Kostic Lab
An epitope-enriched immunogen expands responses to a conserved viral site (Cell Reports)
Schmidt Lab
A microbial transporter of the dietary antioxidant ergothioneine (Cell)
Kranzusch Lab
Two broadly conserved families of polyprenyl-phosphate transporters (Nature)
Rudner Lab
The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella (mBio)
Helaine Lab
What bacterial cell death teaches us about life (PLOS Pathogens)
Kranzusch Lab
Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine (Nature Communications)
Kranzusch Lab
Antibiotic tolerance and persistence have distinct fitness trade-offs (PLOS Pathogens)
Helaine Lab
Intrinsically disordered protein regions are required for cell wall homeostasis in Bacillus subtilis (Genes & Development)
Rudner Lab
CRISPR-Cas9 expressed in stably transduced cell lines promotes recombination and selects for herpes simplex virus recombinants (Current Research in Virological Science)
Knipe Lab
Cryo-EM structure of an active bacterial TIR–STING filament complex (Nature)
Kranzusch Lab
WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae (eLife)
Control of innate immunity by the cGAS-STING pathway (Immunology & Cell Biology)
Kagan Lab
Decoding the Alphaviruses (Harvard Magazine)
Abraham Lab
A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae (Toxins)
Mekalanos Lab
The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages (Nature Communications)
Lory Lab
Discovery of a Novel Species of Trichomonasvirus in the Human Parasite Trichomonas vaginalis Using Transcriptome Mining (Viruses)
Nibert Lab
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells (Nature Communications)
Rouskin Lab
Rapid Inhibitor Discovery by Exploiting Synthetic Lethality (J. Am. Chem. Soc.)
Walker Lab
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite (Cell)
Rakoff-Nahoum Lab
Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling (PLOS Pathogens)
Gewurz Lab
Bacterial gasdermins reveal an ancient mechanism of cell death (Science)
Kranzusch Lab