Advanced Imaging Specialist Position Available

The MicRoN core (Microscopy Resources On the North Quad) is a light microscopy core at Harvard Medical School that serves ~75 different groups throughout the Longwood Medical Area. The core currently hosts 14 instruments including widefield, TIRF, spinning disc confocal, scanning confocal, multiphoton and super-resolution SIM-TIRF. We would like to invite applications for an experienced Advanced Imaging Specialist. The successful candidate will be part of an enthusiastic team of microscopists to assist and train researchers in their advanced imaging and data analysis needs.    

The Advanced Imaging Specialist will work closely with the MicRoN users to provide expertise on experimental design, develop and implement advanced imaging protocols, as well as provide data processing and image analysis solutions. S/he will train graduate students and postdoctoral fellows in the core instruments, especially in the more advanced imaging techniques. Additionally, s/he will maintain and customize the microscopes and software in the MicRoN core to meet advanced users needs and allow novel imaging experiments to be performed. The Advanced Imaging Specialist will assist the Core Director in organizing and teaching light microscopy courses and workshops. 

The successful candidate must have a PhD in Biology, Biophysics, Optical Engineering or related field. S/he must have a wide understanding of various imaging techniques and hands-on experience on imaging biological samples along with expertise in image processing and analysis (ImageJ, Imaris, Matlab…). S/he will be costumer service-oriented, demonstrate willingness to help our researchers and have excellent communication skills. Experience working with users in a core facility and experience in cell culture and immunostaining is preferred.

To apply, please email a PDF file that contains your CV and a cover letter to paula_monterollopis@hms.harvard.edu, adding “Application for Advanced Imaging Specialist” as a subject line.  Please include the earliest or latest start dates in your cover letter. We are looking forward to hearing from you!

Application deadline: April 30th. 2021

Posted March 23, 2021


Translational Medicine Scientist

Type: Full-time
Location: Research Triangle Park, North Carolina

Locus Biosciences is seeking highly motivated applicants to join our development team as a full-time Scientist involved in planning and implementing pre-clinical studies. This position is well suited for innovative scientists that have a desire to lead their scientific efforts from the bench and a passion to develop and pursue multiple avenues to complete research objectives. This individual will work directly with our internal team and external collaborators to develop and deliver preclinical animal models including sample analysis and data interpretation. The ideal candidate will have a significant record of accomplishment of having independently designed and implemented novel research approaches and prioritized multiple concurrent projects. This individual must be able to communicate effectively in formal and informal settings and be able to work well across interdisciplinary teams. Candidates from various molecular biology, synthetic biology and microbial backgrounds with experience in running in vivo animal models are encouraged to apply.

Responsibilities will include:
• Gaining familiarity with the literature surrounding animal models of infectious disease and microbiome
• Coordinating with external collaborators and CROs to develop animal models for a variety of indications
• Establishing protocols for pre-clinical testing of Locus products
• Collaborating with an internal team to process samples from animal models (e.g. phage titration, microbiome profiling, qPCR)
• Analyzing data from animal models and preparing reports
• Actively engaging on overall experimental strategy and direction
• Presenting results to internal scientists, external collaborators, and Locus management
• Coordinating with cross-functional teams

Candidate must possess:
• A PhD in microbiology, microbial genetics, synthetic biology, genetic engineering or similar fields
• A strong track record of infectious disease and/or microbiome model development in small rodents
• Ability to structure, implement and maintain study plans in the face of ambiguity
• Ability to coordinate across internal and external partners to deliver on-time results
• Willingness to develop solutions to difficult objectives independently and consistently

Preferred qualifications:
• At least two years’ experience between postdoctoral or industry research
• Detailed knowledge of infectious disease or microbiome, associated organisms and animal models
• General understanding of the overall drug development lifecycle, especially preclinical phases
• Experience with computational tools analyzing communities of microbes (16S, whole genome sequencing, metagenome sequencing, transcriptome sequencing, RNAseq) is highly desirable

For immediate consideration, please email your resume or CV to: locuscareers@locus-bio.com.
Direct applicants only. No agencies please

Posted March 23, 2021


Position Available -  Research Rigor and Reproducibility Curriculum Fellow

Institution:      Harvard Medical School
Location:        Boston, MA
Category:       Faculty - Science
Type:              Full Time

The Research Rigor and Reproducibility (R3) initiative at Harvard Medical School (HMS) in Boston, Massachusetts is seeking an innovative, collaborative science educator to serve as R3 Curriculum Fellow (CF). The R3 CF will ­develop teaching curricula, work with faculty to modernize biomedical research training, and support the development and administration of the HMS R3 program. The fellow will be a member the HMS Curriculum Fellows Program (CFP), a postdoctoral training program for biomedical scientists interested in a variety of education-focused careers. CFs work full-time with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training while receiving mentorship and career advising to support their development as educators.

Advances in modern biomedical research require the continuous development of and support for a culture that advances research rigor and reproducibility (R3). HMS is committed to identifying, exploring, and supporting R3 principles relevant to our research community through cross-discipline conversations and collaborations. The HMS R3 Committee supports R3 through organizational development, training and educational programs, and resources and tools for our students, trainees, faculty, and staff. The R3 CF will be a critical contributor to those efforts.

Based in the Office for Academic and Research Integrity and working closely with the Office of Research Operations and the Curriculum Fellows Program, the R3 Curriculum Fellow will provide support for the HMS R3 Working Group and Faculty Advisory Committee. The CF will play a key role in developing R3-related curriculum and in cataloguing, developing, implementing, and maintaining HMS resources related to research rigor and reproducibility. Some specific duties and responsibilities of the R3 Fellow will include:

  1. Assisting the R3 committee and R3 Working Group in the planning, implementation, data collection, review, and presentation of an HMS community-wide R3 Preliminary Landscape Analysis
  2. Working with HMS Graduate and Medical Education units, the Office for Postdoctoral Fellows, HMS faculty, and others to expand and develop R3-relevant curricula and training programs at HMS, and to make available some basic R3 course material as online training modules via the Harvard Training Portal
  3. Assisting the R3 committee and R3 Working Group in the development, implementation, and maintenance of the HMS R3 website

Qualifications:

  • An earned Ph.D. in a biomedical science
  • The ability to interact with various R3 stakeholders including faculty at all levels, information technology professionals, and project managers
  • Postdoctoral research or teaching experience (preferred)
  • Demonstrated interest in the metascience of research and data integrity, data management
  • Knowledge of the research data lifecycle in the academic laboratory environment
  • Job Skills and Competencies:
    Strong interest in keeping up with emerging trends, best practices, and new knowledge in the fields of data management, the research data lifecycle, and information technology
    Ability to engage with faculty, administrators, other researchers, and lab managers to integrate their input and ensure R3 projects fully reflect their directives and priorities
    Strong organizational skills, communication skills (written, oral and presentation); a concern for accuracy, details, and quality
    Tolerance of ambiguity and uncertainty in a constantly evolving field
    Adaptability and ability to prioritize work and to be flexible in job tasks
    Highly self-motivated and directed

The Curriculum Fellow’s appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The R3 Curriculum Fellow position is open for an immediate start. Applications are currently being accepted and reviewed on a rolling basis with the goal of filling the position as soon as possible.

To apply:

Applicants should include a single PDF document containing:

(1) a letter of application that addresses your interest in and qualifications for the position

(2) a curriculum vitae

(3) a teaching statement

(4) the names and contact information of three professional references

Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.
Posted August 21, 2020


Position Available - CryoEM Specialist

Cryo-EM Specialist

Harvard Medical School houses two core facilities providing access to negative stain and cryo-EM instrumentation; we are looking for a highly motivated scientist to join our team.  The Harvard Cryo-EM Center for Structural Biology, formed as a consortium between HMS, Boston Children's Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital, serves the consortium members and a variety of external academic and commercial users (https://cryoem.hms.harvard.edu/).  The Molecular Electron Microscopy Suite is a training resource for Quad-based researchers at Harvard Medical School.  The successful candidate will provide support and training for researchers seeking to learn cryo-EM and negative-stain EM in these two facilities, serving as an interface between the instrumentation and a vibrant scientific community.  The candidate will work closely with a team of scientists to support COVID-19 and related projects in many research areas and will take on facility management responsibilities.

Key Roles:

  • Serve as the technical interface between users and the Talos Arctica and Titan Krios microscopes by loading samples and checking microscope alignments.
  • Train users to operate TEM microscopes, specifically the Tecnai T12, Talos Arctica, and Titan Krios; including sample preparation (negative stain and cryo-plunging), grid loading, sample screening, and data collection.
  • Advise researchers on experimental strategy and, when appropriate, collaborate with them to assist in data acquisition, analysis and structure determination, particularly with COVID-19-related work.
  • Interact closely with the core facilities’ team to manage microscope and equipment maintenance, coordinate user scheduling and training, and interface with SBGrid to assist with the computational needs of both facilities.

This position will have a high degree of independence, opportunities to present at regional and national scientific symposia and workshops, and opportunities to develop collaborative relationships with Harvard community investigators.

Requirements:

  • Ph.D. in a field related to structural biology such as cell biology or biochemistry. Experience in structural biology at the postdoctoral level is desired. 
  • Experience with negative stain EM and cryo-EM.  Cryo-electron tomography practical application and analysis experience is valuable.
  • Must be detail-oriented and able to manage multiple projects simultaneously.
  • Good communication and interpersonal skills.

Harvard is an Affirmative Action/Equal Opportunity Employer. Applications from women and minority candidates are strongly encouraged. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

To apply, please submit a cover letter and CV to the director, Dr. Stephen Harrison, via schadmin@crystal.harvard.edu.  In the Subject line of your email, please write: Cryo-EM Specialist.

-Posted Aug 14, 2020