2023

How Dormant Bacteria Return to Life (HMS News&Research)
Rudner Lab

 

The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes (PNAS)
Rudner Lab

 

Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus (Antimicrobial Agents and Chemotherapy)
Walker Lab

 

Bacterial spore germination receptors are nutrient-gated ion channels (Science)
Rudner Lab

 

RNA levers and switches controlling viral gene expression (Trends in Biochemical Sciences)
Rouskin Lab

 

Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles (Journal of Virology)
Sodroski Lab

 

A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW (Angewandte Chemie)
Walker Lab

 

Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems (mSystems)
Kostic Lab

 

IFNγ is a central node of cancer immune equilibrium (Cell Reports)
Knipe and Dougan Labs

 

Silvi Rouskin talks about understanding and using RNA to treat human disease (Science Matters)
Rouskin Lab

 

Key Molecules for Bacterial Growth, Infection Identified (HMS News & Research)
Rudner Lab

 

Coordination of bacterial cell wall and outer membrane biosynthesis (Nature)
Bernhardt and Walker Labs

 

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex (Cell)
Kranzusch Lab

 

Invasion of the germinal centers (Cell)
Schmidt Lab

 

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases (Science Immunology)
Kranzusch Lab

 

2022

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors (eLife)
Jost Lab

 

Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness (NanoToday)
Gehrke Lab
 
Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design (Cell Reports Medicine)
Schmidt Lab

 

The emerging landscape of spatial profiling technologies (Nature Review Genetics)
Moffitt Lab

 

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells (Biochemistry)
Rouskin Lab

 

Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis (Microbiome)
Kostic Lab

 

An epitope-enriched immunogen expands responses to a conserved viral site (Cell Reports)
Schmidt Lab

 

A microbial transporter of the dietary antioxidant ergothioneine (Cell)
Kranzusch Lab

 

Two broadly conserved families of polyprenyl-phosphate transporters (Nature)
Rudner Lab

 

The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella (mBio)
Helaine Lab

 

What bacterial cell death teaches us about life (PLOS Pathogens)
Kranzusch Lab

 

Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine (Nature Communications)
Kranzusch Lab

 

Antibiotic tolerance and persistence have distinct fitness trade-offs (PLOS Pathogens)
Helaine Lab

 

Intrinsically disordered protein regions are required for cell wall homeostasis in Bacillus subtilis (Genes & Development)
Rudner Lab

 

CRISPR-Cas9 expressed in stably transduced cell lines promotes recombination and selects for herpes simplex virus recombinants (Current Research in Virological Science)
Knipe Lab

 

Cryo-EM structure of an active bacterial TIR–STING filament complex (Nature)
Kranzusch Lab

 

WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae (eLife)
Bernhardt / Rudner Labs

 

Control of innate immunity by the cGAS-STING pathway (Immunology & Cell Biology)
Kagan Lab

 

Decoding the Alphaviruses (Harvard Magazine)
Abraham Lab

 

A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae (Toxins)
Mekalanos Lab

 

The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages (Nature Communications)
Lory Lab

 

Discovery of a Novel Species of Trichomonasvirus in the Human Parasite Trichomonas vaginalis Using Transcriptome Mining (Viruses)
Nibert Lab

 

Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells (Nature Communications)
Rouskin Lab

 

Rapid Inhibitor Discovery by Exploiting Synthetic Lethality (J. Am. Chem. Soc.)
Walker Lab

 

Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite (Cell)
Rakoff-Nahoum Lab

 

Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling (PLOS Pathogens)
Gewurz Lab

 

Bacterial gasdermins reveal an ancient mechanism of cell death (Science)
Kranzusch Lab

 

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