July 20, 2022
CRISPR-Cas9 expressed in stably transduced cell lines promotes recombination and selects for herpes simplex virus recombinants
Read More (Current Research in Virological Science)
Knipe Lab
July 20, 2022
Cryo-EM structure of an active bacterial TIR–STING filament complex
Read More (Nature)
Kranzusch Lab
May 20, 2022
WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae
Read More (eLife)
Bernhardt / Rudner Labs
April 29, 2022
Control of innate immunity by the cGAS-STING pathway
Read More (Immunology & Cell Biology)
Kagan Lab
April 21, 2022
Decoding the Alphaviruses
Read More (Harvard Magazine)
Abraham Lab
March 18, 2022
A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae
Read More (Toxins)
Mekalanos Lab
March 2, 2022
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
Read More (Nature Communications)
Rouskin Lab
February 17, 2022
Rapid Inhibitor Discovery by Exploiting Synthetic Lethality
Read More (J. Am. Chem. Soc.)
Walker Lab
February 3, 2022
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite
Read More (Cell)
Rakoff-Nahoum Lab
February 2, 2022
Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling
Read More (PLOS Pathogens)
Gewurz Lab
January 13, 2022
Bacterial gasdermins reveal an ancient mechanism of cell death
Read More (Science)
Kranzusch Lab
December 20, 2021
Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain
Read More (Nature)
Abraham Lab
December 2, 2021
Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain
Read More (Science)
Abraham Lab
December 2, 2021
CYB561A3 is the key lysosomal iron reductase required for Burkitt B-cell growth and survival
Read More (blood)
Gewurz Lab
November 16, 2021
A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein Interactions
Read More (mBio)
Hochschild Lab
October 14, 2021
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses
Read More (Science Immunology)
Schmidt Lab
October 13, 2021
Watch: Merck’s Covid pill could transform treatment. Here’s how it works
Read More (Stat )
Benjamin Gewurz Quoted
October 12, 2021
Antibiotic persistence and tolerance: not just one and the same
Read More (Current Opinion in Microbiology)
Helaine Lab
October 12, 2021
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages
Read More (Cell)
Kranzusch Lab
September 23, 2021
Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing
Read More (Nature Chemical Biology)
Helaine Lab
September 7, 2021
Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall
Read More (PNAS)
Walker Lab
August 25, 2021
The LpoA activator is required to stimulate the peptidoglycan polymerase activity of its cognate cell wall synthase PBP1a
Read More (PNAS)
Bernhardt Lab
August 18, 2021
Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
Read More (Nature Communications)
Higgins Lab
August 6, 2021
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β–converting enzyme
Read More (Science Immunology )
Kagan Lab
July 20, 2021
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Read More (Cell)
Kagan Lab
July 20, 2021
Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival
Read More (mBio)
Gewurz Lab
July 14, 2021
cGAS-like receptors sense RNA and control 3′2′-cGAMP signaling in Drosophila
Read More (Nature)
Kranzusch Lab
June 8, 2021
Polar Growth in Corynebacterium glutamicum Has a Flexible Cell Wall Synthase Requirement
Read More (mBio)
Bernhardt Lab
May 18, 2021
Scientists link genetic makeup of bacteria in the human gut to several human diseases
Read More (Harvard Gazette)
Kostic Lab
May 13, 2021
Reconstruction of ancient microbial genomes from the human gut
Read More (Nature )
Kostic Lab
May 12, 2021
The History of Microbiology - A Personal Interpretation
Read More (Annual Review of Microbiology )
Roberto Kolter
May 11, 2021
Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells
Read More (Immunity )
Kagan Lab
April 14, 2021
Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns
Read More (mBio )
Kagan Lab
March 16, 2021
SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
Read More (Harvard News & Research )
Abraham Lab
March 15, 2021
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
Read More (Nature Communications )
Gewurz Lab
March 15, 2021
Protein Substrates Engage the Lumen of O-GlcNAc Transferase's Tetratricopeptide Repeat Domain in Different Ways
Read More (Biochemistry )
Walker Lab
March 15, 2021
Deep-sea microbes as tools to refine the rules of innate immune pattern recognition
Read More (Science Immunology )
Kagan Lab
March 11, 2021
Coronavirus-specific antibody cross reactivity in rhesus macaques following SARS-CoV-2 vaccination and infection
Read More (Journal of Virology )
Schmidt Lab
Barouch Lab
March 1, 2021
Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity
Read More ( PLoS Pathogens )
Abraham Lab
February 26, 2021
Vaccines can get us to herd immunity, despite the variants
Read More ( The Harvard Gazette )
Abraham Lab
February 25, 2021
Multi-kingdom ecological drivers of microbiota assembly in preterm infants
Read More ( Nature )
Rakoff-Nahoum Lab
February 24, 2021
Toward a comprehensive analysis of posttranscriptional regulatory networks: A new tool for the identification of small RNA regulators of specific mRNAs
Read More ( mBio )
Lory Lab
February 16, 2021
Dissecting serotype-specific contributions to live oral cholera vaccine efficacy
Read More ( PNAS )
Waldor Lab
February 11, 2021
Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency
Read More ( Nature Microbiology )
Knipe Lab
February 9, 2021
Herpes simplex virus 1 manipulates host cell antiviral and proviral DNA damage responses
Read More ( mBio )
Knipe Lab
February 1, 2021
Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes
Read More ( PLOS Pathogens )
Knipe Lab
February 1, 2021
Impact of bacterial persisters on their host
Read More ( Current Opinion in Microbiology )
Helaine Lab
January 29, 2021
Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
Read More ( PLoS Pathogens )
Dong Lab
January 26, 2021
Factors that mold the nuclear landscape of HIV-1 integration
Read More ( Nucleic Acids Research )
Engelman Lab
January 11, 2021
Increased Listeria monocytogenes dissemination and altered population dynamics in Muc2-deficient mice
Read More ( Infection and Immunity )
Waldor Lab
November 17, 2020
Ensuring vaccine safety
Read More ( Science )
Knipe Lab
November 16, 2020
Lipoteichoic acid polymer length is determined by competition between free starter units
Read More ( PNAS )
Walker Lab
October 19, 2020
How Coronavirus Drugs Are Helping Patients
Read More ( AARP )
Abraham Lab
September 14, 2020
A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase
Read More ( PNAS )
Bernhardt Lab
September 4, 2020
STING cyclic dinucleotide sensing originated in bacteria
Read More ( Nature )
Kranzusch Lab
July 22, 2020
Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike.
Read More ( Nature )
Sodroski Lab
July 20, 2020
Coronavirus vaccine from Oxford and AstraZeneca shows positive response in early trial
Read More ( CNBC )
Jonathan Abraham quoted
June 17, 2020
CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection
Read More ( Cell )
Kranzusch Lab
June 11, 2020
Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity
Read More ( Cell Reports )
Sodroski Lab
May 26, 2020
DNA vaccine protection against SARS-CoV-2 in rhesus macaques
Read More ( Science )
Schmidt Lab
May 13, 2020
Massachusetts research consortium (MassCPR) announces funding for projects to combat COVID-19
Read More ( MassCPR )
Abraham Lab Lab
Gehrke Lab
Knipe Lab
April 30, 2020
Suzanne Walker Elected to the National Academy of Sciences
Read More ( Harvard News & Research )
Walker Lab
April 20, 2020
Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope
Read More ( ACS Infectious Diseases )
Schmidt Lab
April 13, 2020
Despite physical distancing, HMS Quad scientists ramp up efforts to combat COVID-19
Read More ( HMS News & Research )
Schmidt Lab
To stem the coronavirus crisis, Harvard Medical School scientists forge ahead on six key fronts
March 31, 2020
Read More ( Ending the Pandemic)
Abraham Lab, Knipe Lab
Global phenotypic profiling identifies a conserved actinobacterial cofactor for a bifunctional PBP-type cell wall synthase
March 16, 2020
Read More ( eLife)
Bernhardt Lab
The Tol-Pal system is required for peptidoglycan-cleaving enzymes to complete bacterial cell division
March 11, 2020
Read More ( PNAS)
Bernhardt Lab
Cooperating to Combat Coronavirus
February 24, 2020
Read More ( Harvard Magazine)
Knipe Lab
Five Questions: A conversation with Ann Hochschild
February 18, 2020
Read More ( Harvard Medicine)
Hochschild Lab
Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes
January 27, 2020
Read More ( The Journal of biological chemistry)
Walker Lab
Research in mice shows antibodies derived from mom’s gut microbes protect newborns from E. coli infection
January 8, 2020
Read More (PNAS)
Bernhardt Lab
A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation
December 30, 2019
Read More ( The Journal of biological chemistry)
Yang Lab
Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis
December 6, 2019
Read More ( eLife)
Rudner Lab
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9
December 2, 2019
Read More ( HMS News )( eLife)
Knipe Lab
Faculty and staff save resources while setting an example for health and wellness
November 12, 2019
Read More ( The path to sustainable commuting)
Jon Beckwith
A Quest for Better Vaccines
September 30, 2019
Read More ( Five Questions: A conversation with Darren Higgins)
Higgins Lab
The Landscape of Genetic Content in the Gut and Oral Human Microbiome
August 14, 2019
Read More (Cell Host & Microbe)
Kostic Lab
Cholera toxin promotes pathogen acquisition of host-derived nutrients
August 2, 2019
Read More (Nature)
Mekalanos Lab
A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-terminal domain of capsid
July 2, 2019
Read More (Antiviral Research)
Engelman Lab
Epstein-Barr-virus-induced one-carbon metabolism drives B cell transformation
July 2, 2019
Read More (Cell Metabolism)
Gewurz Lab
Study finds performance-enhancing bacteria in human microbiome
June 26, 2019
Read More (The Harvard Gazette)
Kostic Lab
HCF-1 regulates de novo lipogenesis through a nutrient-sensitive complex with ChREBP
June 26, 2019
Read More (Molecular Cell)
Walker Lab
Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope
May 21, 2019
Read More (Cell Host & Microbe)
Schmidt Lab
When we stop thinking about microbes as cells
May 15, 2019
Read More (Journal of Molecular Biology)
Kolter Lab
RNA ligands activate the Machupo virus polymerase and guide promoter usage
May 14, 2019
Read More (PNAS)
Whelan Lab
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity
April 16, 2019
Read More (Science Translational Medicine)
Knipe Lab
How Penicillin Acts Like TNT for Bacteria
April 09, 2019
Read More (Howard Hughes Medical Institute)
Bernhardt / Rudner Labs