2024
Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections (mBio)
Gehrke Lab
Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators (mBio)
Knipe Lab
Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells (Journal of Virology)
Sodroski Lab
Tracing the evolutionary origins of antiviral immunity (PLOS Biology)
Kranzusch Lab
Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa (Nature Microbiology)
Bernhardt Lab
Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics (PNAS)
Hochschild Lab
Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation (ACS infect Dis)
Schmidt Lab
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination (Genes Dev.)
Rudner Lab
Structural basis of Gabija anti-phage defence and viral immune evasion (Nature)
Kranzusch Lab
2023
Nuclear interferon-stimulated gene product maintains heterochromatin on the herpes simplex viral genome to limit lytic infection (PNAS)
Knipe Lab
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins (Journal of Virology)
Sodroski Lab
A role for the Gram-negative outer membrane in bacterial shape determination (PNAS)
Bernhardt Lab
Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis (PNAS)
Rudner Lab
MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases (mBio)
Bernhardt and Rudner Labs
How Dormant Bacteria Return to Life (HMS News&Research)
Rudner Lab
The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes (PNAS)
Rudner Lab
Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus (Antimicrobial Agents and Chemotherapy)
Walker Lab
Bacterial spore germination receptors are nutrient-gated ion channels (Science)
Rudner Lab
RNA levers and switches controlling viral gene expression (Trends in Biochemical Sciences)
Rouskin Lab
Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles (Journal of Virology)
Sodroski Lab
A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW (Angewandte Chemie)
Walker Lab
Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems (mSystems)
Kostic Lab
IFNγ is a central node of cancer immune equilibrium (Cell Reports)
Knipe and Dougan Labs
Silvi Rouskin talks about understanding and using RNA to treat human disease (Science Matters)
Rouskin Lab
Key Molecules for Bacterial Growth, Infection Identified (HMS News & Research)
Rudner Lab
Coordination of bacterial cell wall and outer membrane biosynthesis (Nature)
Bernhardt and Walker Labs
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex (Cell)
Kranzusch Lab
Invasion of the germinal centers (Cell)
Schmidt Lab
Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases (Science Immunology)
Kranzusch Lab