2023
How Dormant Bacteria Return to Life (HMS News&Research)
Rudner Lab
The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes (PNAS)
Rudner Lab
Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus (Antimicrobial Agents and Chemotherapy)
Walker Lab
Bacterial spore germination receptors are nutrient-gated ion channels (Science)
Rudner Lab
RNA levers and switches controlling viral gene expression (Trends in Biochemical Sciences)
Rouskin Lab
Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles (Journal of Virology)
Sodroski Lab
A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW (Angewandte Chemie)
Walker Lab
Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems (mSystems)
Kostic Lab
IFNγ is a central node of cancer immune equilibrium (Cell Reports)
Knipe and Dougan Labs
Silvi Rouskin talks about understanding and using RNA to treat human disease (Science Matters)
Rouskin Lab
Key Molecules for Bacterial Growth, Infection Identified (HMS News & Research)
Rudner Lab
Coordination of bacterial cell wall and outer membrane biosynthesis (Nature)
Bernhardt and Walker Labs
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex (Cell)
Kranzusch Lab
Invasion of the germinal centers (Cell)
Schmidt Lab
Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases (Science Immunology)
Kranzusch Lab
2022
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors (eLife)
Jost Lab
Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness (NanoToday)
Gehrke Lab
Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design (Cell Reports Medicine)
Schmidt Lab
The emerging landscape of spatial profiling technologies (Nature Review Genetics)
Moffitt Lab
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells (Biochemistry)
Rouskin Lab
Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis (Microbiome)
Kostic Lab
An epitope-enriched immunogen expands responses to a conserved viral site (Cell Reports)
Schmidt Lab
A microbial transporter of the dietary antioxidant ergothioneine (Cell)
Kranzusch Lab
Two broadly conserved families of polyprenyl-phosphate transporters (Nature)
Rudner Lab
The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella (mBio)
Helaine Lab
What bacterial cell death teaches us about life (PLOS Pathogens)
Kranzusch Lab
Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine (Nature Communications)
Kranzusch Lab
Antibiotic tolerance and persistence have distinct fitness trade-offs (PLOS Pathogens)
Helaine Lab
Intrinsically disordered protein regions are required for cell wall homeostasis in Bacillus subtilis (Genes & Development)
Rudner Lab
CRISPR-Cas9 expressed in stably transduced cell lines promotes recombination and selects for herpes simplex virus recombinants (Current Research in Virological Science)
Knipe Lab
Cryo-EM structure of an active bacterial TIR–STING filament complex (Nature)
Kranzusch Lab
WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae (eLife)
Bernhardt / Rudner Labs
Control of innate immunity by the cGAS-STING pathway (Immunology & Cell Biology)
Kagan Lab
Decoding the Alphaviruses (Harvard Magazine)
Abraham Lab
A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae (Toxins)
Mekalanos Lab
The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages (Nature Communications)
Lory Lab
Discovery of a Novel Species of Trichomonasvirus in the Human Parasite Trichomonas vaginalis Using Transcriptome Mining (Viruses)
Nibert Lab
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells (Nature Communications)
Rouskin Lab
Rapid Inhibitor Discovery by Exploiting Synthetic Lethality (J. Am. Chem. Soc.)
Walker Lab
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite (Cell)
Rakoff-Nahoum Lab
Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling (PLOS Pathogens)
Gewurz Lab
Bacterial gasdermins reveal an ancient mechanism of cell death (Science)
Kranzusch Lab