2024

Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections (mBio)
Gehrke Lab

Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators (mBio)
Knipe Lab

Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells (Journal of Virology)
Sodroski Lab

Tracing the evolutionary origins of antiviral immunity (PLOS Biology)
Kranzusch Lab

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa (Nature Microbiology)
Bernhardt Lab

Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics (PNAS)
Hochschild Lab

Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation (ACS infect Dis)
Schmidt Lab

SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination (Genes Dev.)
Rudner Lab

Structural basis of Gabija anti-phage defence and viral immune evasion (Nature)
Kranzusch Lab

2023

Nuclear interferon-stimulated gene product maintains heterochromatin on the herpes simplex viral genome to limit lytic infection (PNAS)
Knipe Lab

V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins (Journal of Virology)
Sodroski Lab

A role for the Gram-negative outer membrane in bacterial shape determination (PNAS)
Bernhardt Lab

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis (PNAS)
Rudner Lab

MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases (mBio)
Bernhardt and Rudner Labs

How Dormant Bacteria Return to Life (HMS News&Research)
Rudner Lab

The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes (PNAS)
Rudner Lab

Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus (Antimicrobial Agents and Chemotherapy)
Walker Lab

Bacterial spore germination receptors are nutrient-gated ion channels (Science)
Rudner Lab

RNA levers and switches controlling viral gene expression (Trends in Biochemical Sciences)
Rouskin Lab

Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles (Journal of Virology)
Sodroski Lab

A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW (Angewandte Chemie)
Walker Lab

Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems (mSystems)
Kostic Lab

IFN╬│ is a central node of cancer immune equilibrium (Cell Reports)
Knipe and Dougan Labs

Silvi Rouskin talks about understanding and using RNA to treat human disease (Science Matters)
Rouskin Lab

Key Molecules for Bacterial Growth, Infection Identified (HMS News & Research)
Rudner Lab

Coordination of bacterial cell wall and outer membrane biosynthesis (Nature)
Bernhardt and Walker Labs

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex (Cell)
Kranzusch Lab

Invasion of the germinal centers (Cell)
Schmidt Lab

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases (Science Immunology)
Kranzusch Lab

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